Obesity is a very complex metabolic disease and not a problem of willpower or self-control. It’s not simply about eating less and moving more!The etiology of obesity is multifactorial and not yet well understood but some of the contributors are genetic factors, unhealthy diet, physical inactivity, lack of sleep, disruptions in circadian rhythm, stress hormones, medical conditions, psychosocial problems, environmental factors, and weight gain-promoting mediations, among others.There are some hormonal imbalances that can contribute to weight gain, such as hypothyroidism (under-active thyroid gland), Cushing’s Syndrome (high cortisol levels), or imbalances of satiety (Leptin) and hunger (Ghrelin) hormones.We have to fight obesity stigma, bias, prejudice, and discrimination. Healthcare professionals should show empathy and use nonjudgmental language. Rule out possible causes. Discuss different treatment options, and offer helpful referrals. Multidisciplinary team approach is the key to success.Customize your treatment plan for every person with obesity, remember that one size doesn’t fit all.Figure from EASO (The European Association for the Study of Obesity).